Cytotoxic pDCs

Tolerogenic pDCs: spotlight on Foxo3.

Cancer creates a peculiar inflammatory environment enriched for transcription factors with a negative influence on adaptive immunity. In this issue of the JCI, Watkins and colleagues identify Foxo3 as a master regulator of the tolerogenic program in tumor-associated, plasmacytoid DCs (pDCs). Foxo3 enables pDCs to induce tolerance in tumor antigen-specific CD8+ T cells, turning them into regulat...

CD4- plasmacytoid dendritic cells (pDCs) migrate in lymph nodes by CpG inoculation and represent a potent functional subset of pDCs.

We have recently identified two groups of plasmacytoid dendritic cells (pDCs) isolated from murine liver based on the expression of CD4 and other cell surface markers uniquely expressed by pDCs. Herein, we describe the identification of both CD4+ and CD4- pDCs that clearly exist in lymph nodes (LNs), spleen, liver, thymus, bone marrow, and lung. Normally, CD4+ pDCs are enriched in LNs. However,...

Emergency and the Pdcs: the Experience in Trieste (*)

The CFH Optical PDCS survey ( COP ) I : The Data

This paper presents and gives the COP (COP: CFHT Optical PDCS; CFHT: Canada-France-Hawaii Telescope; PDCS: Palomar Distant Cluster Survey) survey data. We describe our photometric and spectroscopic observations with the MOS multi-slit spectrograph at the CFH telescope. A comparison of the photometry from the PDCS (Postman et al. 1996) catalogs and from the new images we have obtained at the CFH...

IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity

Plasmacytoid dendritic cells (pDCs) have been shown to both mediate and prevent autoimmunity, and the regulation of their immunogenic versus tolerogenic functions remains incompletely understood. Here we demonstrate that, compared to other cells, pDCs are the major expressors of Indoleamine-2,3-dioxygenase (IDO) in steady-state lymph nodes (LNs). IDO expression by LN pDCs was closely dependent ...